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Abstract
Long-term oral vitamin C supplementation may reduce transcriptomic age estimates by approximately 4 years in primate bone marrow.
- Bone marrow aging is associated with significant depletion of common lymphoid progenitors (CLPs) and a shift towards myeloid-biased hematopoietic stem and progenitor cell (HSPC) output.
- Vitamin C supplementation is linked to an expansion of the CLP pool and a rebalancing of lineage commitment trajectories.
- Molecular adaptations in aging bone marrow occur in a site-specific manner.
- Cell-cell communication analyses indicate that vitamin C alters intercellular signaling, potentially through a progranulin-linked pathway.
- In human in vitro assays, recombinant progranulin replicates some molecular effects associated with vitamin C supplementation.
Simplified
Longevity & Aging