Vortioxetine for the treatment of major depression

Vortioxetine has been effective in various animal models of depression and anxiety and shows antidepressant and antianxiety properties in a dose range of 5-20 mg/day.

• Vortioxetine has a multi-modal mechanism of action involving the inhibition of serotonin transporters and interaction with several serotonin receptors.
• The molecule is associated with reversing cognitive decline in patients with depression.
• Vortioxetine appears to lack serious side effects and drug-drug interactions.
• Dose adjustments may be necessary when vortioxetine is taken with rifampicin or bupropion.
• The compound is currently under review by various regulatory agencies for the treatment of major depression.

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