Where the VPAC2 receptor is found in mouse body tissues

The VPAC(2) receptor is predominantly located in smooth muscle tissues, the colon, lung, kidney vasculature, adrenal medulla, and retina.

• The VPAC(2) receptor is found mainly in smooth muscle layers of blood vessels and the gastrointestinal and reproductive systems.
• Significant receptor presence was noted in the basal part of the mucosal epithelium in the colon.
• Unexpectedly, the receptor was also identified in thyroid follicular cells and acinar cells of the pancreas, which is not seen in other species.
• The receptor is present in very large amounts in the lung.
• These findings suggest novel functions and potential therapeutic uses for drugs targeting the VPAC(2) receptor.
• Caution is advised when using mice as a model for evaluating VIP analogs intended for human use.

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