Scientific reportsSep 6, 2024

Link between waist size adjusted for weight and circadian health problems in a nationwide study

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Apr 5, 2026

Abstract

In a study of 8,275 subjects, (WWI) is significantly positively related to (CircS) with an odds ratio of 1.77.

Higher WWI values are associated with increased likelihood of CircS.
Subgroup analysis confirmed the stability of the positive association between WWI and CircS.
An inverted U-shaped relationship was identified, with a turning point of 11.84 for WWI concerning CircS.
Management of central obesity may be important for preventing or alleviating CircS.

Simplified

(WWI) is an emerging parameter for evaluating obesity. We sought to ascertain the link between WWI and (CircS). The study population consisted of 8275 eligible subjects who were included in the ultimate analysis from the NHANES 2011-2018. By using multivariable regression models, the association of WWI and CircS was analyzed. In subgroup analysis, we explored the relationship in different groups and tested the stability of the intergroup connection using interaction testing. To investigate whether WWI and CircS had a potential non-linear relationship, smooth curve fittings, and threshold effects tests were also constructed. In a multivariate linear regression model, WWI is significantly positively related to CircS (OR = 1.77, 95% CI 1.50-2.08). Through subgroup analysis and interaction testing, the stability of this positive association was also validated. It was further found that there was an inverted U-shaped association, with a turning point of 11.84, between WWI and CircS. Our findings supported a strong association between WWI values and CircS. Central obesity management is pivotal for preventing or alleviating CircS.

Key numbers

1.77

Odds Ratio for Increase

Measured in a multivariable logistic regression model.

11.84

Turning Point for

Identified through threshold effect analysis.

28.17%

Prevalence

Observed among the study population of 8275 adults.

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Link between waist size adjusted for weight and circadian health problems in a nationwide study

Abstract

Key numbers

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