The was developed to measure emotional functioning in adults with obesity or overweight.
Evidence
This patient-reported outcome development study used interviews with 40 Phase 2 trial participants, a literature review, 3 clinician interviews, and cognitive interviews with 20 adults with obesity or overweight and at least 1 related complication.
Caveat
The abstract reports content understanding and perceived importance, but not psychometric validation or responsiveness in larger independent samples.
Simplified
OBJECTIVE: Obesity and overweight are associated with significant psychosocial burden. Existing patient-reported outcome (PRO) measures only assess a subset of emotion-related concepts that are relevant to individuals living with these conditions. The (WES) was developed to enable robust evaluation of the impact of obesity or overweight and the benefits of treatment on patients' emotional functioning.
METHODS: The WES was developed based on findings from interviews with participants ( = 40) exiting a Phase 2 trial for retatrutide (NCT04881760), a targeted literature review, and interviews with clinicians specialized in obesity medicine ( = 3). Cognitive interviews were conducted with adults with obesity/overweight and ≥ 1 obesity-related complication ( = 20) to evaluate the WES content. N N N
RESULTS: All cognitive interview participants expressed a positive overall impression of the WES, reported that they understood the instructions, response options, and recall period, and that the questions were easy to answer. Most items (75%) were understood by all the participants and were rated as "very important" or "moderately important" by ≥ 75% of the participants. The WES is a new 16-item PRO measure evaluating 13 emotion-related concepts.
CONCLUSIONS: The WES may be used in clinical trials, observational research, or clinical practice to robustly assess the impact of obesity or overweight and the benefits of treatment on patients' emotional functioning.
Key numbers
20
Cognitive Interview Participants
Participants evaluated the during .
75%
Items Rated as Important
Percentage of items rated as very or moderately important.
13
Concepts Evaluated
Number of emotion-related concepts assessed by the .
Full Text
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Chisom Kanu, Iris Goetz, Lisa M. Neff, and Kristina S. Boye are employees and shareholders of Eli Lilly and Company, which funded this study. Jessica Jordan and Miriam Kimel are current employees of Evidera, which was paid by Eli Lilly and Company to conduct this study. The Weight and Emotions Scale (WES) is copyrighted by Eli Lilly and Company and is free for use once permission is obtained. For permission to reproduce or use the WES, contact copyright@lilly.com.
