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Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist
Weight loss and blood sugar control with SAR441255, a drug activating three hormone receptors
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Abstract
SAR441255, a synthetic peptide, shows high potency in activating GLP-1, GIP, and GCG receptors.
- Unimolecular triple incretins like SAR441255 may reduce body weight and improve glucose control in rodent models.
- Metabolic outcomes with SAR441255 are superior to those with a dual GLP-1/GCG receptor agonist.
- Preclinical imaging indicates that SAR441255 binds to GLP-1 and GCG receptors.
- In healthy subjects, SAR441255 improves glycemic control during a mixed-meal tolerance test.
- Single doses of SAR441255 are reported to be well tolerated.
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