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Abstract
GLP-1 receptor agonists (GLP-1Ras) may help restore satiety signaling disrupted by antipsychotic-induced weight gain (AIWG).
- AIWG can lead to significant obesity and metabolic issues in children and adolescents.
- Metformin is the standard treatment for AIWG, but its effectiveness is often limited.
- Preclinical and translational studies indicate that targeting the underlying mechanisms of AIWG may be beneficial.
- Restoring disrupted satiety signaling could be a potential approach to improving outcomes for patients on antipsychotics.
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