MetabolitesOct 27, 2026

Weight gain after stopping GLP-1 and GIP/GLP-1 hormone treatments: A systematic review

GLP-1 Therapies Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Oct 28, 2026

Abstract

Weight regain and loss of cardiometabolic benefit may occur following the withdrawal of glucagon-like peptide-1 receptor agonists (GLP-1RAs).

Withdrawal of GLP-1RAs is associated with increased weight regain.
Loss of cardiometabolic benefits may follow the cessation of these medications.
Maintenance strategies for preventing these outcomes are not fully characterized.

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