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Green Synthesis of Zinc Oxide Nanoparticles from Althaea officinalis Flower Extract Coated with Chitosan for Potential Healing Effects on Diabetic Wounds by Inhibiting TNF-α and IL-6/IL-1β Signaling Pathways
Eco-Friendly Zinc Oxide Nanoparticles Made from Marshmallow Flower Extract and Coated with Chitosan May Help Heal Diabetic Wounds by Reducing Inflammation Signals
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Abstract
(ZnO-NPs) synthesized from Althaea officinalis demonstrated a mean size of 76 nm and showed significant antibacterial properties.
- The green-synthesized ZnO-NPs displayed a peak absorbance at 390 nm during UV-visible spectrum analysis.
- Energy-dispersive X-ray spectrometry confirmed the presence of zinc and oxygen in the nanoparticles.
- The antibacterial efficacy of the formulation was assessed, revealing notable inhibition against both Gram-positive and Gram-negative bacteria.
- In in-silico studies, major components showed a potential binding affinity to targets associated with wound healing.
- The A.O.-ZnO-NPs formulation resulted in decreased levels of inflammatory markers IL-6, IL-1β, and TNF-α, while increasing IL-10 levels.
- Histopathological analysis indicated a reduction in inflammation and improved wound healing in rat models treated with the nanoparticles.
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Key numbers
98.1%
Wound Contraction Percentage Increase
Wound contraction percentage in group treated with ZnO-NPs gel.
Reduced downregulation of IL-6
IL-6 Level Decrease
Comparison of IL-6 levels in treated vs. control groups.
22.51 mm
Diameter of Zone of Inhibition
Zone of inhibition observed in antibacterial susceptibility testing.