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ZuoGui Pill Ameliorates Alzheimer’s Disease–Like Pathology in 3xTg-AD Mice by Targeting Aβ Production, Tau Phosphorylation, Synaptic Loss, and Neuroinflammation
ZuoGui Pill may improve Alzheimer's-like symptoms in mice by reducing harmful protein buildup, nerve cell loss, and brain inflammation
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Abstract
(ZGP) treatment for 60 days significantly improved cognitive performance in a transgenic Alzheimer's disease mouse model.
- ZGP treatment reduced hippocampal amyloid-β deposition and BACE1 expression.
- Suppression of tau phosphorylation was observed at multiple pathological sites (T205, S396, S404).
- Restoration of synaptic markers and increased dendritic spine density were noted.
- ZGP decreased levels of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α in the hippocampus.
- Inhibition of the RAGE/NF-κB signaling pathway was associated with neuroinflammation reduction.
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Key numbers
3 of 6
Cognitive Improvement
Proportion of groups showing improved performance in cognitive tests.
2.3×
Reduction in Aβ Levels
Magnitude of decrease in Aβ levels in -treated mice.
3 of 6
Decreased Tau Hyperphosphorylation
Proportion of groups showing reduced p-Tau levels.