Phytomedicine : international journal of phytotherapy and phytopharmacology

Indole-3-propionic acid boosts cell cleanup and reduces cell death in blood vessel disease by targeting the 14-3-3θ protein

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Indole-3-propionic acid (IPA) is a microbiota-derived tryptophan metabolite that may have vascular protective effects.

  • IPA is associated with potential benefits for vascular health.
  • The exact mechanisms by which IPA affects endothelial function in atherosclerosis are not fully understood.
  • Further investigation is needed to clarify how IPA interacts with the vascular system.

Simplified

Full Text

Full text is available at the source.
View Full Text ↗

Related papers

Jul '26
Astragaloside IV may reduce artery plaque by controlling cell cleanup and stress through the Nrf2/PINK1/Parkin pathway
top 20% journal
Jul '26
Gut bacteria product indole-3-propionic acid helps reduce fat-related liver damage by promoting cell cleanup processes
top 30% journal
Sep '25
Dingxin Recipe III may reduce blood vessel cell aging in atherosclerosis by activating a protective cell cleanup pathway
top 20% journal
cited by 4 papers
journal article
Jan '21
Scutellarin helps protect blood vessel lining cells from high sugar damage by activating cell cleanup through PINK1/Parkin
top 20% journal
cited by 81 papers
journal article
Feb '26
Boosting Mitochondrial Cleanup with PEP-1-CAT Reduces Blood Vessel Inflammation and Plaque Build-Up in Mice
top 20% journal
journal article
Apr '26
NPC1L1 speeds up artery disease by boosting cell recycling and iron-related cell death through CYP11A1, helped by PABPC1 and IGF2BP1
top 10% journal
journal article

What Lands in Your Inbox Each Week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the longevity & aging brief

issue #53
Your biological age can reverse — but scientists are still debating what that actually means
1 week ago7 studies
issue #52
Deleting a DNA-sensing protein accelerates aging in mice — the opposite of what scientists expected
2 weeks ago6 studies
issue #51
A cancer drug already in clinics may slow aging by quieting a key inflammatory signal
3 weeks ago7 studies
issue #50
Senescent brain cells linked to age-related myelin loss via a newly identified signaling molecule
4 weeks ago7 studies
issue #49
One month of vegan eating left measurable epigenetic marks on biological aging clocks
5 weeks ago7 studies
issue #48
Mitochondrial metabolism secretly controls how inflammatory senescent cells actually get loud
6 weeks ago7 studies
issue #47
Cutting one amino acid from mice's diet extended male lifespan by 23%
7 weeks ago7 studies
issue #46
Vitamin C cut 4 years off primate bone marrow's biological age in a new study
8 weeks ago7 studies
issue #45
Sweetened drinks are linked to faster biological aging, especially if you're under 55
9 weeks ago7 studies
issue #44
Stress ages your blood stem cells — and the gut microbiome is the middleman
10 weeks ago7 studies
explore the archive
See more issues from the longevity & aging brief