Effects of 5-nitro-2-(3-phenylpropylamino) benzoic acid, anthracene-9-carboxylate, and zaprinast on endothelin-1-induced contractions of pregnant rat myometrium

NPPB and 9-AC significantly increased the amplitude of contractions in pregnant rat myometrium starting from a concentration of 10(-6)M.

• NPPB and 9-AC increased the amplitude of contractions while decreasing their frequency in a concentration-dependent manner.
• The amplitude of contractions was significantly increased by NPPB and 9-AC beginning at 10(-6)M.
• The frequency of contractions was significantly decreased by NPPB and 9-AC starting from 10(-6)M.
• Zaprinast inhibited both the amplitude and frequency of contractions in a concentration-dependent manner.
• Statistical significance for zaprinast's effects on amplitude was noted starting at 10(-7)M and for frequency at 10(-5)M.
• The findings suggest that chloride channels may play a role in modulating ET-1-induced contractions in the myometrium.

AI simplified