How endothelin-1 and calcium blockers affect contractions in uterine muscle from normal and diabetic pregnant women
Updated
Abstract
ET-1 significantly increased the amplitude of contractions in myometrial strips from diabetic women starting at concentrations of 10(-9) M.
- Nimodipine and isradipine significantly decreased the amplitude of contractions in both normal and diabetic myometrial strips.
- The amplitude of contractions was significantly higher in diabetic strips compared to normal strips at concentrations of 10(-9) M and 10(-8) M.
- ET-1 also increased the frequency of contractions in both normal and diabetic myometrial strips, but no significant difference in frequency was observed between the two groups.
- Nimodipine and isradipine did not significantly decrease the frequency of contractions in diabetic strips, except for specific concentrations of nimodipine in normal strips.
- The contractile effects of ET-1 in both normal and diabetic myometrial tissue may be partly mediated by calcium channels.
Simplified