Full text is available at the source.
A comprehensive review on the antidiabetic attributes of thiazolidine‐4‐ones: Synthetic strategies and structure–activity relationships
Thiazolidine-4-ones as antidiabetic agents: How they are made and how their structure affects their activity
AI simplified
Abstract
The thiazolidine-4-one scaffold shows potential for antidiabetic drug development.
- The thiazolidine-4-one structure is linked to various biological activities, particularly antidiabetic effects.
- Its antidiabetic activity is associated with interactions with targets such as peroxisome proliferator-activated receptor γ and protein tyrosine phosphatase 1B.
- Recent developments include exploring structural modifications at C-2, N-3, and C-5 of the thiazolidine-4-one ring.
- The review summarizes synthetic strategies, structure-activity relationships, and docking studies related to thiazolidine-4-ones.
- This compilation may aid in the design of new antidiabetic drug candidates based on the thiazolidine-4-one core.
AI simplified