Thiazolidine-4-ones as antidiabetic agents: How they are made and how their structure affects their activity

The thiazolidine-4-one scaffold shows potential for antidiabetic drug development.

• The thiazolidine-4-one structure is linked to various biological activities, particularly antidiabetic effects.
• Its antidiabetic activity is associated with interactions with targets such as peroxisome proliferator-activated receptor γ and protein tyrosine phosphatase 1B.
• Recent developments include exploring structural modifications at C-2, N-3, and C-5 of the thiazolidine-4-one ring.
• The review summarizes synthetic strategies, structure-activity relationships, and docking studies related to thiazolidine-4-ones.
• This compilation may aid in the design of new antidiabetic drug candidates based on the thiazolidine-4-one core.

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