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Multicomponent reaction for the synthesis of new 1,3,4-thiadiazole-thiazolidine-4-one molecular hybrids as promising antidiabetic agents through α-glucosidase and α-amylase inhibition
New hybrid molecules made by a multistep reaction that may help diabetes by blocking sugar-digesting enzymes
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Abstract
Compound 4e exhibited an IC50 value of 2.59 μM for α-glucosidase and α-amylase inhibition.
- The new library of thiazolidine-4-one molecular hybrids was synthesized through a one-pot multicomponent reaction.
- In vitro evaluations indicated that compound 4e showed superior antidiabetic activity compared to the standard inhibitor acarbose.
- The study found that the structure and position of substituents on the phenyl rings significantly influenced the inhibitory potency.
- Antioxidant and antimicrobial potentials of the synthesized compounds were also assessed.
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