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Facile synthesis and in silico studies of benzothiazole-linked hydroxypyrazolones targeting α -amylase and α -glucosidase
Easy creation and computer analysis of benzothiazole-linked hydroxypyrazolones targeting enzymes that break down starch and sugar
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Abstract
Twenty new benzothiazole-appended indenopyrazoles were synthesized and tested for antidiabetic activity.
- The synthesized compounds were evaluated for their ability to inhibit the enzymes α-amylase and α-glucosidase.
- Two specific compounds demonstrated the best inhibitory effects against both enzymes.
- Molecular docking and dynamic studies supported the observed antidiabetic activity.
- These findings suggest that the identified compounds may serve as promising candidates for further development in antidiabetic treatments.
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