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New compounds based on polyhydroquinoline that may strongly block enzymes related to diabetes and prevent sugar damage: synthesis, enzyme tests, and computer modeling
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Abstract
Seven compounds exhibited notable α-amylase inhibitory activity with IC values ranging from 3.51 ± 2.13 to 11.92 ± 2.30 µM.
- Six compounds demonstrated potent α-glucosidase inhibitory activity compared to the standard acarbose.
- Eight derivatives showed excellent anti-glycating activity with IC values from 6.91 ± 2.66 to 15.80 ± 1.87 µM, outperforming the standard rutin.
- Molecular docking analysis indicated strong interactions between most compounds and the enzymes α-amylase and α-glucosidase.
- Compounds fit well into the binding pockets of α-amylase and α-glucosidase.
- Compounds 2a and 2f were identified as the most potent based on docking scores against both enzymes.
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