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New carbazole-oxadiazole compounds as inhibitors of enzymes involved in sugar digestion: design, testing, and computer modeling
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Abstract
Most of the tested carbazole-oxadiazole derivatives displayed varying degrees of α-glucosidase and α-amylase inhibitory activity, with IC values ranging from 21.39 ± 0.69 to 126.14 ± 6.33 μM.
- Compound 6c exhibited the highest anti-α-glucosidase activity with an IC value of 21.39 ± 0.69 μM.
- Compound 6e showed the most effective anti-α-amylase activity with an IC value of 45.53 ± 1.50 μM.
- Lineweaver-Burk plot analysis indicated that 6c acts as a mixed inhibitor of α-glucosidase.
- 6e was identified as a mixed inhibitor of α-amylase.
- Molecular docking simulations suggested specific interaction mechanisms for both 6c and 6e with their target enzymes.
- The potential for reducing postprandial blood glucose levels, along with favorable oral activity and low cytotoxicity, supports the consideration of these compounds as lead candidates for new hypoglycemic agents.
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