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Abstract
The new thiazole derivatives showed significant potential as alpha-glucosidase inhibitors, particularly compounds 3, 5, and 7.
- Compounds 3, 5, and 7 demonstrated the strongest inhibition of alpha-glucosidase activity in vitro compared to the control.
- Compounds 4 and 7 were identified as the most effective alpha-amylase inhibitors, with ICscore values approaching that of the control (Acarbose).
- Compound 4 exhibited a lower ferric-reducing antioxidant power (FRAP) value compared to ascorbic acid in control experiments.
- Molecular docking studies indicated favorable binding affinity and modes for compounds 4 and 5 at the alpha-glucosidase and alpha-amylase binding sites.
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