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Accelerated biological aging and homeostatic dysregulation in diabetic kidney disease: Evidence from NHANES and Mendelian randomization
Faster biological aging and body balance problems linked to diabetic kidney disease: Evidence from population data and genetic analysis
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Abstract
Accelerated biological aging status (BioAgeAccel > 0) substantially increased diabetic kidney disease (DKD) odds (OR = 3.25, 95% CI: 2.52-4.18).
- Significant nonlinear threshold effects were observed, with DKD risk increasing markedly at BioAgeAccel > 2.13 years and (HD) > 3.16 units.
- PhenoAgeAccel exhibited a linear dose-response relationship with DKD risk.
- The highest quartile of HD was associated with elevated risk (Q4 OR = 2.85, 95% CI: 1.87-4.36).
- Urinary albumin-to-creatinine ratio mediated 89% to 93% of the associations between all aging metrics and DKD.
- Discriminatory accuracy for HD was highest (AUC = 0.678), followed by BioAgeAccel (AUC = 0.660) and PhenoAgeAccel (AUC = 0.562).
- Mendelian randomization confirmed a causal effect of PhenoAgeAccel on DKD risk, but not for BioAgeAccel.
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Key numbers
1.04
Increased Risk per Year
Continuous odds ratio for KDMage increase.
2.13 years
Risk Threshold for
Identified threshold for associated with .
3.16 units
Increased Risk for
Threshold for linked to .