Molecular and cellular endocrinology

Daily changes in stress hormone effects linked to chemical modifications controlling its receptor

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

The circadian rhythm-related transcription factor Clock acetylates the glucocorticoid receptor, affecting its activity.

  • Clock acetylates lysines in the hinge region of the glucocorticoid receptor, which contains a specific lysine cluster.
  • This acetylation represses the transcriptional activity of the glucocorticoid receptor.
  • The repression occurs in an inversely phased manner to the levels of circulating glucocorticoids throughout the day.
  • Disruption of the CLOCK-regulated hypothalamic-pituitary-adrenal axis and peripheral glucocorticoid action may lead to functional hypercortisolism.
  • Such disruptions could be linked to conditions like chronic stress, frequent time zone changes, or night-shift work.
  • The acetylation process may play a crucial role in ensuring proper glucocorticoid action, impacting human health and longevity.

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