Cureus

Sudden Pancreas Inflammation Linked to Semaglutide in a Patient with Multiple Health Conditions

Updated

Abstract

A 59-year-old man developed acute pancreatitis after 2.5 years of weekly semaglutide therapy.

  • The patient had multiple underlying conditions, including type 2 diabetes and stage IIIA colon cancer.
  • Symptoms included epigastric pain and elevated lipase levels.
  • Abdominal ultrasound indicated mild pancreatic parenchymal heterogeneity but no fluid collection.
  • The patient improved with conservative management after discontinuing semaglutide.
  • No recurrence of symptoms was noted during three months of follow-up.
  • The case suggests a potential risk of pancreatitis associated with semaglutide in patients with multimorbidity.

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Funding

Competing interests

Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Taipei Medical University - Joint Institutional Review Board issued approval N202511072. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.
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