Future cardiology

Semaglutide as an important medicine for managing combined heart, kidney, and metabolism problems

Updated

Abstract

Semaglutide may reduce major adverse cardiovascular events (MACE) by 26% in high cardiovascular-risk patients with type 2 diabetes.

  • In type 2 diabetes, semaglutide improves glycemic control and slows chronic kidney disease progression.
  • The SUSTAIN-6 trial indicated a 26% reduction in MACE among patients taking semaglutide at doses of 0.5 or 1.0 mg weekly.
  • The FLOW trial found a 24% reduction in major kidney disease events with 1.0 mg semaglutide in individuals with type 2 diabetes and chronic kidney disease.
  • The SELECT trial demonstrated a 20% reduction in MACE with weekly 2.4 mg semaglutide in overweight or obese individuals with preexisting cardiovascular disease.
  • Semaglutide also alleviates heart failure symptoms and reduces hospitalizations in obese individuals, regardless of type 2 diabetes status.

Simplified

Key numbers

26%
MACE Reduction
Reduction in major adverse cardiovascular events in patients with T2D.
24%
Kidney Disease Event Reduction
Reduction in major kidney disease events in T2D patients with CKD.
20%
MACE Reduction in Obese Patients
Reduction in major adverse cardiovascular events in overweight or obese individuals with preexisting CV disease.

Full Text

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Funding

Competing interests

R MacIsaac has received research grants from Novo Nordisk, Servier, Medtronic, The Rebecca Cooper Medical Research Foundation, St Vincent’s Research Foundation, The Juvenile Diabetes Research Foundation, Grey Innovations, The Diabetes Australia Research Trust/Program and The National Health and Medical Research Council of Australia. He has also received honoraria for lectures from Eli Lilly, Novo Nordisk, Sanofi Aventis, Astra Zeneca, Merck Sharp & Dohme, Novartis and Boehringer Ingelheim. He is on the advisory boards for Novo Nordisk, Boehringer Ingelheim-Eli Lilly Diabetes Alliance, Astra Zeneca, and Merck Shape and Dohme. Novo Nordisk, Sanofi, Boehringer Ingelheim and Astra Zeneca have supplied travel support. He has been a principal investigator for industry-sponsored clinical trials by Novo Nordisk, Sanofi, Bayer, Johnson-Cilag and AbbVie. He was an investigator for the semaglutide trials SUSTAIN-6 and FLOW and was on the global expert panel for the FLOW trial. The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Brad Dalton of medScript Communications provided medical writing and editorial support for this article, which Novo Nordisk funded.
PubMed

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