Adjusting weight maintenance after hormone-related weight loss: new strategies beyond just continuing or stopping treatment

Weight regain after reducing or stopping GLP-1 receptor agonists may reflect biological pressures favoring weight restoration.

• GLP-1 receptor agonists and dual GLP-1/GIP receptor agonists are effective in treating obesity.
• Weight regain is a significant challenge following dose reduction or discontinuation of these treatments.
• The phenomenon of post-treatment weight regain may be linked to the body's natural tendencies to restore weight.
• This suggests that weight regain may not solely indicate treatment failure.

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