Regulation of adiponectin and its receptors in response to development of diet-induced obesity in mice

Circulating adiponectin levels decrease after 10 weeks of high-fat feeding in DIO-prone C57BL/6J mice.

• C57BL/6J mice exhibit higher baseline circulating adiponectin and adiponectin expression in white adipose tissue compared to A/J mice.
• Adiponectin levels increase at 10 weeks but decline at 18 weeks in response to high-fat feeding and advancing age.
• High-fat feeding leads to a decrease in adiponectin levels corrected for visceral fat mass and adiponectin mRNA expression in C57BL/6J mice after 10 weeks.
• Muscle and liver expression of AdipoR1 increases in both mouse strains at 18 weeks, with additional increases in AdipoR2 expression in the liver.
• High-fat feeding is associated with increased expression of AdipoR1 and AdipoR2 in the liver and enhanced muscle AdipoR1 expression in C57BL/6J mice after 18 weeks.

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