Adipose Tissue Circadian Dysregulation Beyond BMI: Implications for Cardiometabolic Risk and Cardiovascular Disease

Circadian misalignment could disrupt adipose tissue function, leading to impaired lipid handling and inflammation.

• Individuals with similar body mass index (BMI) can exhibit different metabolic and cardiovascular outcomes.
• Adipose tissue has intrinsic circadian clocks that regulate lipid storage, insulin sensitivity, and immune activity.
• Circadian disruptions, such as those caused by shift work or irregular sleep patterns, may lead to adipose tissue dysfunction.
• Dysregulation of circadian rhythms is associated with conditions like insulin resistance and atherosclerosis.
• Different adipose tissue depots, including visceral and epicardial fat, may be affected differently by circadian misalignment.
• Chrononutrition and time-restricted eating may offer strategies for improving cardiometabolic health.

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