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Adrenergic control of the adaptive immune response by diurnal lymphocyte recirculation through lymph nodes
How adrenaline-related signals regulate immune response by daily movement of immune cells through lymph nodes
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Abstract
Lymphocyte egress from lymph nodes is reduced at night due to inputs from adrenergic nerves.
- Diurnal variations in lymphocyte recirculation through lymph nodes are linked to the time of day.
- Neural inputs to β-adrenergic receptors on lymphocytes affect their movement, with fewer lymphocytes leaving lymph nodes at night.
- Increased lymphocyte accumulation in lymph nodes at night correlates with enhanced antibody responses following immunization.
- The dependence of humoral immune response on β-adrenergic signaling suggests a novel mechanism for immune system rhythms.
- Stopping lymphocyte recirculation through lymph nodes diminishes the observed diurnal variation in immune responses.
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