The European journal of neuroscience

How Aging and Alzheimer's Disease Together Affect Daily Body Clock Rhythms

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Aging is associated with changes in circadian rhythms, including decreased amplitude and altered synchrony.

  • Circadian rhythm alterations are more pronounced in age-associated neurodegenerative disorders, particularly Alzheimer's disease.
  • Fragmentation of daily rest-activity rhythms in non-demented older individuals is linked to earlier cognitive decline and increased risk of developing Alzheimer's disease.
  • Disruption of circadian rhythms may contribute to the development and progression of neuropathological changes in Alzheimer's disease.
  • Amyloid-beta accumulation in Alzheimer's disease has been implicated in the impairment of circadian rhythms.
  • There may be an interaction between circadian rhythm disruption and neurodegeneration in Alzheimer's disease, forming a harmful cycle.

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