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Interacting influences of aging and Alzheimer's disease on circadian rhythms
How Aging and Alzheimer's Disease Together Affect Daily Body Clock Rhythms
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Abstract
Aging is associated with changes in circadian rhythms, including decreased amplitude and altered synchrony.
- Circadian rhythm alterations are more pronounced in age-associated neurodegenerative disorders, particularly Alzheimer's disease.
- Fragmentation of daily rest-activity rhythms in non-demented older individuals is linked to earlier cognitive decline and increased risk of developing Alzheimer's disease.
- Disruption of circadian rhythms may contribute to the development and progression of neuropathological changes in Alzheimer's disease.
- Amyloid-beta accumulation in Alzheimer's disease has been implicated in the impairment of circadian rhythms.
- There may be an interaction between circadian rhythm disruption and neurodegeneration in Alzheimer's disease, forming a harmful cycle.
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