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Aging Map Shows How Different Cell Types Control Life-Extending Processes

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗

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Abstract

Single-cell transcriptomic atlases reveal age-related changes in Caenorhabditis elegans across different cell types.

  • Distinct aging patterns were observed in somatic and germ cell types throughout the lifespan of the organism.
  • Transcriptomic aging clocks were developed to assess how aging varies in different tissues.
  • Tissue-specific effects of various pro-longevity mechanisms on slowing aging were identified.
  • Major cell types responsive to pro-longevity strategies were pinpointed.
  • Alternative polyadenylation events exhibited cell-type-specific alterations during aging and under pro-longevity conditions.

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Competing interests: Authors declare that they have no competing interests.
PubMed

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