The effects of aging and chronic fluoxetine treatment on circadian rhythms and suprachiasmatic nucleus expression of neuropeptide genes and 5‐HT1Breceptors

Jun 8, 2010The European journal of neuroscience

How Aging and Long-Term Fluoxetine Use Affect Daily Body Clocks and Brain Signals Controlling Them

AI simplified

Circadian BiologyCircadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Aging decreases SCN expression of mRNA for gastrin-releasing peptide, which modulates photic phase resetting.

  • Age-related changes in circadian rhythms may be linked to alterations in the central pacemaker in the suprachiasmatic nucleus (SCN).
  • Aging decreases the expression of mRNA for vasoactive intestinal peptide (VIP) and increases expression of serotonin transporters and 5-HT(1B) receptors.
  • Chronic administration of the serotonin-selective reuptake inhibitor fluoxetine does not affect SCN VIP mRNA expression in either age group.
  • Fluoxetine treatment prevents the age-related increase in SCN 5-HT(1B) receptors at ZT6 and decreases them in both age groups at ZT13.
  • Aging and chronic fluoxetine treatment result in decreased total daily wheel running without changing the phase of the circadian wheel running rhythm.

AI simplified

Full Text

Full text is available at the source.
View full text ↗

Related papers

Nov '05
Short-term constant light increases large daily rhythm shifts caused by 8-OH-DPAT, affecting serotonin receptors and gene activity in the hamster’s internal clock
top 20% journal
cited by 15 papers
comparative study
Aug '18
Specialized Brain Cells Needed for Normal Light-Based Resetting of the Body’s Internal Clock
top 5% journal
cited by 148 papers
research support, n.i.h., extramural
Nov '07
Gastrin-releasing peptide helps reset the body’s internal clock by activating key proteins in the brain’s timing center
top 5% journal
cited by 84 papers
research support, n.i.h., extramural
Feb '01
Vasoactive intestinal polypeptide shifts the timing of the rat's brain internal clock in a lab setting
top 20% journal
cited by 126 papers
research support, non-u.s. gov't
Jan '08
Serotonin boosts light’s ability to reset the body clock and changes clock gene activity in a daytime rodent
cited by 70 papers
research support, non-u.s. gov't
Jul '01
Resetting the hamster's internal clock through serotonin receptors in the brain's daily rhythm center
top 5% journal
cited by 115 papers
research support, u.s. gov't, p.h.s.

what lands in your inbox each week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #36
Night owls show 77% higher risk of job burnout among firefighters
1 week ago7 studies
issue #35
Bacteria exposure resets your internal clock independently of immune responses
2 weeks ago7 studies
issue #34
Night owl teens got 47 minutes more sleep with bright light glasses
3 weeks ago7 studies
issue #33
Working out at your optimal time cuts blood pressure twice as much
4 weeks ago7 studies
issue #32
Bright light preference disrupts mouse sleep patterns even without human lifestyle factors
5 weeks ago7 studies
issue #31
Artificial light at night disrupts bird sleep and metabolism across 675 studies
6 weeks ago7 studies
issue #30
Your hair can reveal your circadian rhythm from a single sample
7 weeks ago7 studies
issue #29
Your body clock needs 25% more epidural painkiller at night
8 weeks ago7 studies
issue #28
Night owls have 123% higher mortality risk after age 81
9 weeks ago7 studies
issue #27
Light pollution linked to 31% higher diabetes risk in major analysis
10 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief