The European journal of neuroscience

How Aging and Long-Term Fluoxetine Use Affect Daily Body Clocks and Brain Signals Controlling Them

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

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Abstract

Aging decreases SCN expression of mRNA for gastrin-releasing peptide, which modulates photic phase resetting.

  • Age-related changes in circadian rhythms may be linked to alterations in the central pacemaker in the suprachiasmatic nucleus (SCN).
  • Aging decreases the expression of mRNA for vasoactive intestinal peptide (VIP) and increases expression of serotonin transporters and 5-HT(1B) receptors.
  • Chronic administration of the serotonin-selective reuptake inhibitor fluoxetine does not affect SCN VIP mRNA expression in either age group.
  • Fluoxetine treatment prevents the age-related increase in SCN 5-HT(1B) receptors at ZT6 and decreases them in both age groups at ZT13.
  • Aging and chronic fluoxetine treatment result in decreased total daily wheel running without changing the phase of the circadian wheel running rhythm.

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