ALKBH5 may promote skin melanoma growth by changing ABCA1 gene regulation and controlling cell recycling through m6A modification

ALKBH5 is upregulated in skin cutaneous melanoma and is associated with poor prognosis.

• ALKBH5 may promote melanoma cell proliferation, colony formation, migration, and invasion.
• ALKBH5 is linked to inhibited autophagy, which could facilitate tumor growth and metastasis.
• ABCA1, a protein that helps remove cholesterol from cells, is identified as a downstream target of ALKBH5.
• ALKBH5 may reduce ABCA1 mRNA stability through mA demethylation, leading to its downregulation.
• The findings highlight the potential role of the ALKBH5-mA-ABCA1 axis in the progression of skin cutaneous melanoma.

Simplified