Functional & integrative genomics

How ALKBH5 helps colorectal cancer resist oxaliplatin by changing NPC2 mRNA

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Updated

Abstract

High expression is associated with oxaliplatin resistance and poor prognosis in colorectal cancer patients.

  • Oxaliplatin is a crucial chemotherapy drug for colorectal cancer but resistance to it often develops.
  • Bioinformatics analysis identified a link between elevated NPC2 levels and decreased treatment effectiveness.
  • NPC2 expression is particularly high in metastatic colorectal cancer tissues.
  • In oxaliplatin-resistant colorectal cancer cells, levels of the mA demethylase ALKBH5 are significantly increased.
  • ALKBH5 enhances the stability of NPC2 mRNA through a specific process, contributing to drug resistance.
  • Inhibiting NPC2 or ALKBH5 may help restore sensitivity to oxaliplatin in resistant colorectal cancer cells.

Simplified

Key numbers

1.679
Increase in expression
Hazard ratio for overall survival based on expression.
4 of 4
Oxaliplatin resistance in CRC cells
All oxaliplatin-resistant CRC cell lines exhibited elevated levels.

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Funding

Competing interests

Declarations. Ethics approval: All procedures of the animal study were approved by the Medical Ethics Committee of Jing Zhou First People’s Hospital (No. KY2025-017-01). Competing interests: The authors declare no competing interests.
PubMed

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