We can’t show the full text here under this license. Use the link below to read it at the source.
Altered Refractive Development in Mice With Reduced Levels of Retinal Dopamine
Changes in Eye Growth in Mice with Lower Retinal Dopamine Levels
AI simplified
Abstract
rTHKO mice exhibited significantly myopic refractions and steeper corneas compared to Ctrl mice.
- Retina-specific knockout (rTHKO) mice showed myopic refractions at 4 and 6 weeks of age.
- rTHKO mice had thinner corneas and retinas, and shorter axial lengths than control mice.
- Dopamine levels in rTHKO retinas were less than 15% of those in control retinas, with a higher turnover rate.
- Responses to form deprivation were similar for rTHKO and control mice, but more variable in rTHKO mice.
AI simplified
Key numbers
3.28 ± 0.27 D
Average Refractive Error Difference
Difference in refractive error between rTHKO and Ctrl mice under normal conditions
0.023 ± 0.003 mm
Corneal Radius of Curvature Difference
Comparison of corneal curvature between rTHKO and Ctrl mice
4.07 ± 1.5 D
Myopic Shift After Form Deprivation
Myopic shift in rTHKO mice after 6 weeks of form deprivation treatment