Lack of cone mediated retinal function increases susceptibility to form-deprivation myopia in mice

Three weeks of form deprivation resulted in a significantly greater myopic shift in Gnat2 mice compared to controls (-5.40 ± 1.33 D vs -2.28 ± 0.28 D, p = 0.042).

• Under normal visual conditions, Gnat2 and control mice exhibited similar refractive error, axial length, and corneal radii throughout development.
• The Gnat2 mutation did not significantly affect normal ocular refractive development in mice (p > 0.05).
• Form deprivation led to a pronounced myopic shift in Gnat2 mice, suggesting that cone signaling may influence myopia susceptibility.
• Neither the Gnat2 mutation nor form deprivation altered retinal levels of dopamine or 3,4-dihydroxyphenylacetate.

AI simplified