Differences in eye growth and retinal dopamine between mice with OFF visual pathway mutations and normal mice

Vsx1-/- mice exhibited myopic refractions of -5.28±0.75 diopter at 4 weeks, which shifted to 3.28±0.82 D by 12 weeks.

• Both Vsx1-/- and Vsx1+/+ mice transitioned from myopic to hyperopic refractions during normal development.
• C57BL/6J mice demonstrated a different refraction pattern, being more hyperopic at younger ages and stabilizing at around 7 weeks.
• Form deprivation did not induce a myopic shift in the 129S1/Sv animals, while a significant myopic shift occurred in C57BL/6J mice.
• At 4 weeks, retinal dopamine turnover was higher in 129S1/Sv mice compared to C57BL/6J mice.
• Form deprivation did not affect dopamine levels between goggled and opposite eyes across genotypes.

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