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Enhanced AMPA Receptor Trafficking Mediates the Anorexigenic Effect of Endogenous Glucagon-like Peptide-1 in the Paraventricular Hypothalamus
Increased AMPA Receptor Movement in the Brain's Appetite Control Area May Help Natural GLP-1 Reduce Hunger
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Abstract
Stimulation of GLP-1 afferent fibers within the paraventricular nucleus (PVN) effectively suppresses food intake.
- GLP-1-expressing neurons in the hindbrain project to the PVN, which plays a role in regulating food intake.
- Activation of GLP-1 receptors in the PVN enhances excitatory signaling in corticotropin-releasing hormone neurons.
- This receptor activation triggers a signaling pathway involving protein kinase A, leading to changes in AMPA receptor function.
- Depleting GLP-1 receptors in the PVN after birth is linked to increased food intake and obesity.
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