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Abstract
Senescence promotes in vitro reprogramming in a stress-dependent manner.
- Cellular senescence is associated with a dynamic secretome, known as the senescence-associated secretory phenotype (SASP).
- Amphiregulin (AREG), a factor secreted by senescent cells, enhances reprogramming by fostering cell growth and transitions from mesenchymal to epithelial states.
- AREG treatment may counteract the negative influence of donor age on reprogramming efficiency.
- In vivo studies indicate that AREG improves reprogramming outcomes in skeletal muscle.
- The findings suggest that various SASP factors could aid in enhancing cellular plasticity for reprogramming and tissue repair.
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