An amygdalar oscillator coordinates cellular and behavioral rhythms

Sep 20, 2024Neuron

A timing system in the emotion center coordinates cell and behavior rhythms

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Abstract

An extra-SCN oscillator in the lateral amygdala is defined by the expression of the clock-output molecule mWAKE/ANKFN1.

  • mWAKE is enriched in the anterior/dorsal lateral amygdala (adLA).
  • Disruption of clock function or excitatory signaling in adLA neurons abolishes Period2 (PER2) rhythms throughout the lateral amygdala.
  • mWAKE levels rise at night and enhance the excitability of adLA neurons by increasing the activity of calcium-activated potassium channels specifically during nighttime.
  • adLA neurons are involved in coordinating rhythmic sensory perception and anxiety in ways dependent on both the clock and mWAKE.

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