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Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms
Amyloid-β build-up in human support brain cells includes shortened and hard-to-break protein forms
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Abstract
Human astrocytes pack aggregated amyloid-beta (Aβ) in a highly resistant form.
- Astrocytes take up large amounts of aggregated Aβ but do not effectively degrade it.
- The ingested Aβ aggregates are transported to lysosomal compartments in astrocytes.
- Astrocytes truncate Aβ aggregates, creating forms that are resistant to degradation.
- Truncated Aβ forms released by astrocytes can expose neighboring cells to pathogenic proteins.
- The findings suggest that astrocytes may play a significant role in the progression of Alzheimer's disease.
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