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Anti-obesity activity of Allium fistulosum L. extract by down-regulation of the expression of lipogenic genes in high-fat diet-induced obese mice
Allium fistulosum extract may reduce obesity by lowering fat-making gene activity in mice fed a high-fat diet
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Abstract
AFE treatment resulted in a significant reduction in body weight and white adipose tissue weight in high-fat diet-induced obese mice.
- AFE reduced adipocyte size in treated mice compared to control.
- Serum levels of triglycerides, total cholesterol, low density lipoprotein-cholesterol, and leptin were significantly decreased with AFE treatment.
- Adiponectin levels in the serum increased following AFE administration.
- AFE suppressed the mRNA expression of key transcription factors and fatty acid synthase in subcutaneous adipose tissue.
- These findings suggest AFE may inhibit fat accumulation and influence lipid concentrations through gene expression modulation.
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