Ethanolic extract of seabuckthorn (Hippophae rhamnoides L) prevents high-fat diet–induced obesity in mice through down-regulation of adipogenic and lipogenic gene expression

Oral administration of seabuckthorn leaf extract significantly reduced body weight gain and fat accumulation in mice.

• Ethanolic extract of seabuckthorn leaves reduced energy intake and epididymal fat pad weight in high-fat diet mice.
• Hepatic triglyceride, total cholesterol levels, and serum leptin levels were significantly lower in mice treated with seabuckthorn leaf extract.
• No significant differences were observed in serum triglyceride and insulin levels between seabuckthorn extract groups and high-fat diet controls.
• Increased expression of certain genes related to fat metabolism was noted in the seabuckthorn extract groups compared to the high-fat diet group.
• Findings suggest seabuckthorn leaf extract may help manage body weight and fat accumulation.

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