Journal of the science of food and agriculture

Nelumbo nucifera seed extract reduces fat cell growth and blood fat levels in human cells and high-fat diet rats

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Abstract

In vivo administration of Nelumbo nucifera seed ethanol extract (NSEE) resulted in significantly reduced body weight gain and adipose tissue weights in rats.

  • In vitro, NSEE inhibited lipid accumulation and reduced the expression of key genes involved in fat cell differentiation.
  • Cultured human pre-adipocytes treated with NSEE showed decreased levels of glucose transporter 4 (GLUT4) and leptin.
  • Rats on a high-fat diet showed lower serum triglyceride and leptin levels when administered NSEE compared to those on the high-fat diet alone.
  • NSEE may have beneficial effects on blood lipid profiles and adipose tissue in the context of obesity.

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