Molecular nutrition & food research

Mangiferin’s helpful effects on high fat–induced high blood fat levels in hamsters

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Mangiferin treatment significantly decreased serum triglyceride concentrations and body weight in hamsters fed a high-fat diet.

  • Forty male hamsters were divided into three groups: normal control, high-fat control, and high fat with mangiferin.
  • Mangiferin at doses of 50 and 150 mg/kg body weight reduced liver weight and visceral fat-pad weight.
  • Hepatic triglyceride levels and total free fatty acid contents in both liver and muscle were significantly decreased with mangiferin treatment.
  • Mangiferin upregulated the expression of genes linked to fat oxidation while downregulating those associated with fat production in the liver.
  • In muscle, mangiferin increased the expression of genes related to fat metabolism.

Simplified

Full Text

Full text is available at the source.
View Full Text ↗

Related papers

Sep '12
Vitamin D reduces fat buildup in the liver caused by a high-fat diet in rats by changing how the body processes fats
top 20% journal
cited by 108 papers
research support, non-u.s. gov't
Nov '12
Seabuckthorn extract may prevent high-fat diet obesity in mice by reducing fat-making gene activity
top 20% journal
cited by 68 papers
research support, non-u.s. gov't
May '14
Persimmon tannin lowers blood fat by activating energy control and reducing inflammation in high-fat diet rats
top 20% journal
cited by 53 papers
research support, non-u.s. gov't

What Lands in Your Inbox Each Week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #50
Afternoon workouts beat morning sessions for fat loss — and your genes may explain why
6 days ago7 studies
issue #49
Your body clock controls which drugs work — and a protein called gp78 is why
1 week ago7 studies
issue #48
A blood test can now estimate your internal clock time using just 60 proteins
2 weeks ago7 studies
issue #47
Your body clock controls liver fibrosis — and scientists just found the on/off switch
3 weeks ago7 studies
issue #46
Night shift workers' metabolomes fall out of sync — and glucose pays the price
4 weeks ago7 studies
issue #45
80% of FDA-approved drug targets show clock-dependent activity — timing may be everything
5 weeks ago7 studies
issue #44
Sleeping late on weekends is independently linked to higher cardiovascular disease risk
6 weeks ago7 studies
issue #43
A smartphone app cut mood episode recurrence 3.4x in people with depression and bipolar disorder
7 weeks ago7 studies
issue #42
Morning cancer immunotherapy linked to 49% vs 40% disease control rate in 969 patients
8 weeks ago7 studies
issue #41
Timing cancer treatment before 3pm nearly doubled survival in lung cancer patients
9 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief