Persimmon Tannin accounts for hypolipidemic effects of persimmon through activating of AMPK and suppressing NF-κB activation and inflammatory responses in High-Fat Diet Rats

High molecular weight persimmon tannin (HMWPT) significantly lowered serum triglycerides and free fatty acids in male Wistar rats on a high-fat diet.

• Administration of HMWPT or persimmon fruit enhanced the excretion of triglycerides, cholesterol, and bile acids.
• HMWPT and persimmon fruit improved liver fat accumulation in rats fed a high-fat diet.
• Dietary HMWPT or persimmon fruit decreased protein levels of fatty acid synthase (FAS) and increased activation of AMP-activated protein kinase (AMPK).
• Regulation of genes involved in fat production, such as sterol regulatory element binding protein 1 (SREBP1) and acetyl CoA carboxylase (ACC), was observed with HMWPT consumption.
• Expression of proteins that support fat breakdown, like carnitine palmitoyltransferase-1 (CPT-1), was notably increased.
• HMWPT and persimmon fruit reduced inflammatory markers such as tumor necrosis factor α (TNFα) and C-reactive protein (CRP), and decreased nuclear factor-kappa B (NFκB) levels in the liver.

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