Pinus Densiflora Bark Extract (PineXol) Decreases Adiposity in Mice by Down-Regulation of Hepatic De Novo Lipogenesis and Adipogenesis in White Adipose Tissue

Jan 13, 2017Journal of microbiology and biotechnology

Pine Bark Extract (PineXol) Reduces Body Fat in Mice by Lowering Fat Production in the Liver and Fat Tissue

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Abstract

PineXol supplementation at 50 mg/kg body weight resulted in statistically lower body weight and body fat mass in mice fed a high-fat diet.

Mice receiving PineXol showed reduced liver triglycerides, total cholesterol, and low-density lipoprotein cholesterol compared to those on a high-fat diet.
Key enzymes involved in lipid synthesis and fat metabolism were significantly decreased in the PineXol-treated group.
In white adipose tissue, markers associated with fat cell development and storage were reduced in the PineXol-treated mice.

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PineXol, extracted from Korean red pine bark, has beneficial effects, such as antioxidant, antiinflammatory, and antilipogenic activities in vitro. We tested the hypothesis that PineXol supplementation could have anti-obesity effects on mice fed a high-fat diet (HFD). Four-week-old male C57BL/6 mice were fed normal chow (18% kcal from fat) or a HFD (60% kcal from fat). HFD-fed animals were also subjected to PineXol treatment at a dose of 10 or 50 mg/kg body weight (BW) (PX10 or PX50, respectively) body weight. The body weight and body fat mass in the PX50 group were statistically lower than those in the HFD group (< 0.05 and< 0.001, respectively). The concentration of hepatic triglycerides, total cholesterol, and low-density lipoprotein cholesterol were reduced in the PX50 group compared with the HFD group (< 0.01). Acetyl CoA carboxylase (< 0.01), elongase of very long chain fatty acids 6 (< 0.01), stearoyl CoA desaturase 1 (< 0.05), microsomal triglyceride transfer protein (< 0.01), and sterol regulatory element-binding protein 1 (< 0.05) were significantly decreased in the PX50 group compared with that in the HFD group. In white adipose tissue, CCAATenhancer-binding protein alpha (< 0.05), peroxisome proliferator-activated receptor gamma (< 0.001), and perilipin (< 0.01) were decreased in the PX50 group compared with those in the HFD group. Therefore, the current study implies the potential of PineXol for the prevention and/or amelioration of obesity, in part by inhibition of both hepatic lipid synthesis and adipogenesis in white adipose tissue. p p p p p p p p p p p

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Pinus Densiflora Bark Extract (PineXol) Decreases Adiposity in Mice by Down-Regulation of Hepatic De Novo Lipogenesis and Adipogenesis in White Adipose Tissue

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