Perilla leaf extract ameliorates obesity and dyslipidemia induced by high‐fat diet

Perilla leaf extract (PLE) supplementation at 1% and 3% significantly decreased body weight gain in mice fed a high fat diet.

• Mice on a high fat diet supplemented with PLE showed lower food efficiency and reduced relative liver and fat mass compared to those on the high fat diet alone.
• Triglyceride, total cholesterol, and LDL levels in the plasma were significantly lower in the PLE supplemented groups than in the high fat diet group.
• Histological analysis indicated that PLE supplementation inhibited liver fat accumulation caused by the high fat diet.
• PLE altered the expression of genes in epididymal fat tissue associated with fat storage and metabolism, suggesting a mechanism for its antiobesity effect.

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