Treatment with Antiobesity Drugs in Weight Regain After Bariatric Surgery: a Retrospective Cohort Study

Of 80 patients with weight regain after bariatric surgery, significant weight loss was observed with topiramate or orlistat over two years.

• The mean age of patients was 59.0 years, with 88.8% being female and 91.2% white.
• The average preoperative weight was 127.9 kg, and the nadir weight after surgery was 84.7 kg.
• At the start of antiobesity medication (AOM), the mean weight was 99.4 kg.
• Participants treated with topiramate alone lost an average of 3.2 kg, while those on topiramate plus sibutramine lost 6.1 kg.
• Orlistat, whether used alone or in combination, resulted in an average weight loss of 3.9 kg.
• No significant weight loss was noted in the group using sibutramine alone.

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