Antispasmodic effects of curcuminoids on isolated guinea-pig ileum and rat uterus.

Curcuminoids at a concentration of 12 microg/ml significantly inhibited contractions in isolated guinea-pig ileum and rat uterus.

• Curcuminoids inhibited ileum contractions induced by acetylcholine and histamine, with a force of contraction of 62.84 +/- 4.66% and 75.60 +/- 4.66% respectively at 12 microg/ml.
• Increasing the concentration of curcuminoids to 36 microg/ml further reduced contraction force to 44.93 +/- 4.33% and 42.79 +/- 1.98% for acetylcholine and histamine.
• In potassium depolarizing solution, curcuminoids at 4 microg/ml and 20 microg/ml reduced contraction caused by calcium chloride, resulting in contractions of 63.31 +/- 1.80% and 36.87 +/- 3.25%.
• Curcuminoids at 8 microg/ml and 16 microg/ml significantly decreased both the force and frequency of contractions in rat uterus smooth muscle induced by oxytocin.
• At 8 microg/ml, curcuminoids produced a force of contraction at 54.68 +/- 3.34% and a frequency of contraction at 79.09 +/- 2.29%.
• The study indicates that curcuminoids may relax smooth muscle in isolated guinea-pig ileum and rat uterus through both receptor-dependent and independent mechanisms.

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