Arrhythmic Gut Microbiome Signatures Predict Risk of Type 2 Diabetes

In a study of 1,976 subjects, 13 taxa of gut bacteria were identified with disrupted rhythmicity associated with type 2 diabetes.

• Certain gut bacteria show 24-hour cycles in their abundance, which may be linked to metabolic health.
• Disrupted microbial oscillations were confirmed in an independent cohort of 1,363 subjects.
• A specific pattern of arrhythmic gut bacteria was able to predict type 2 diabetes in 699 subjects five years later.
• The prediction model for type 2 diabetes was most effective when combined with body mass index (BMI).
• Shotgun metagenomic analysis revealed 26 metabolic pathways potentially linked to the daily rhythms of gut bacteria.

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