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Aspergillus oryzae atfB encodes a transcription factor required for stress tolerance in conidia
A gene in Aspergillus oryzae needed for spores to survive stress
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Abstract
The gene atfB is associated with stress tolerance in conidia, showing reduced expression during vegetative growth.
- Expression of atfB is barely detectable during vegetative growth but increases significantly during conidiation in solid-state culture.
- Microarray analyses indicate that many genes, including catalase (catA), are downregulated in an atfB-disruptant strain.
- Most downregulated genes in the atfB-disruptant show upregulated expression in the wild-type strain during conidiation.
- Conidial germination ratios for both the DeltaatfB strain and wild-type strain are similar under non-stress conditions.
- Conidia lacking atfB exhibit decreased stress tolerance compared to wild-type conidia.
- CRE-like DNA motifs present in the promoters of many downregulated genes suggest a regulatory role for atfB.
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